AEMCA Practice Exam

Which symptom is a common manifestation of Cushing's syndrome related to skin changes?

1. Thickened skin

2. Excessive bruising

3. Hyperpigmentation

4. Loss of elasticity

The correct answer is: Excessive bruising

Excessive bruising is a common manifestation of Cushing's syndrome that relates to skin changes. This condition is characterized by an overproduction of cortisol, a hormone that affects various body systems, including skin integrity. In Cushing's syndrome, the increased cortisol levels can weaken the blood vessels and alter the skin's structural integrity, making it more susceptible to bruising. Typically, people with Cushing's syndrome exhibit thin skin, which can more easily tear and lead to bruising even with minor trauma or friction. This phenomenon occurs because of the degradation of collagen and elastin in the skin, which is exacerbated by excess cortisol. Thus, excessive bruising can serve as a notable symptom of the syndrome, alerting healthcare providers to a possible underlying hormonal imbalance. While thickened skin, hyperpigmentation, and loss of elasticity can also be seen in various skin disorders, they are not the hallmark signs associated with Cushing's syndrome. Instead, the characteristic symptoms involve rather fragile skin that is prone to bruising due to the impact of excessive cortisol on skin and vascular structure.