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The disease stage is defined by the presence of symptoms that are characteristic of the specific infection. At this point, the host shows clinical manifestations that indicate the body is responding to the invading pathogens. Symptoms can include fever, pain, fatigue, or other signs depending on the type of infection, making it clear that the person is infected and experiencing the effects of the disease.

In contrast, the latent stage refers to a period where the infection is present in the body but not yet producing symptoms. The incubation stage is the time between exposure to the pathogen and the onset of symptoms, where the individual may not feel ill yet. The communicability stage relates to the period during which an infected person can transmit the infection to others, which may overlap with the disease stage but does not inherently indicate the presence of symptoms. Thus, the disease stage distinctly marks the shift to a symptomatic presentation of infection.