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Antidepressants are primarily used to treat conditions related to mood and anxiety disorders. Major depressive disorder is the classic condition for which antidepressants are prescribed, as these medications have been shown to effectively alleviate symptoms of depression.

Generalized anxiety disorder also commonly involves the use of antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), which help in managing anxiety symptoms by increasing serotonin levels in the brain.

Chronic pain conditions may not be an obvious indication for antidepressants, but certain types of antidepressants, particularly tricyclic antidepressants, are often used in the management of chronic pain, as they can help modulate pain perception and improve the overall quality of life.

In contrast, while attention deficit hyperactivity disorder (ADHD) can be treated with a range of medications, which may include stimulants and non-stimulants, antidepressants are not typically a first-line treatment. Though some may sometimes be used in combination therapies, they are not commonly prescribed to manage ADHD symptoms. This makes attention deficit hyperactivity disorder the condition that is least associated with the regular use of antidepressants, thereby confirming it as the correct response to the question.