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Naturally occurring opioid peptides in the body, such as endorphins and enkephalins, play a crucial role in managing pain, stress, and emotional responses. These peptides bind to the body’s opioid receptors, leading to pain relief and feelings of euphoria. Endorphins are often released in response to stress or pain and are sometimes dubbed the body’s natural painkillers, while enkephalins are concentrated in the brain and spinal cord, modulating pain perception.

Other options do not represent opioid peptides. Serotonin and dopamine are neurotransmitters involved in regulating mood and cognitive functions. Glutamate and GABA are key players in excitatory and inhibitory neurotransmission, respectively, crucial for brain function and signaling. Cytokines and interferons are part of the immune response and play no role in the opioid system. Thus, endorphins and enkephalins are specifically recognized as the body's naturally occurring opioid peptides.