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Tricyclic antidepressants (TCAs) are known for their ability to affect multiple neurotransmitters in the brain, which is why the statement that they affect multiple neurotransmitters is the best descriptor of their function.

These medications primarily work by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, which increases their levels in the synaptic cleft and enhances mood. This broad action on various neurotransmitter systems contributes to their effectiveness in treating a range of mood disorders, including depression and anxiety, as well as certain chronic pain conditions.

The other statements do not accurately depict the nature of tricyclics. For instance, they do not only block one type of receptor; rather, they interact with several receptor types, contributing to their varied effects and side effects. Although some tricyclics might have hypotensive effects, they are primarily used for treating depression rather than hypertension. Lastly, describing them as exclusively non-selective overlooks their multiple receptor activity and the specificity that some TCAs exhibit in comparison to other psychotropic medications.