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The endocrine system is primarily responsible for controlling hormonal functions in the body. It comprises a network of glands that produce and release hormones directly into the bloodstream. These hormones regulate various physiological processes, including metabolism, growth and development, tissue function, and mood, among others.

Unlike the nervous system, which communicates through electrical signals and neurotransmitters for rapid responses, the endocrine system operates through a slower but prolonged signaling mechanism. Hormones can have widespread effects and operate over longer time frames, influencing various organ systems simultaneously.

The muscular system does not play a role in hormone production or secretion; it primarily focuses on movement and the mechanical functions related to muscle contractions. The circulatory system is responsible for transporting hormones throughout the body but does not control their production or function. Therefore, the endocrine system is the clear choice for the control of hormonal functions in the body.